Engaging Worms for Health

Publications

Short overview article:

• Schramm G, Haas H. Learn from the worm! International Innovation, 2013.
  
  

Selected publications:

• Knuhr K, Langhans K, Nyenhuis S, Viertmann K, Overgaard Kildemoes AM, Doenhoff MJ, Haas H, Schramm G. Schistosoma mansoni Egg-Released IPSE/alpha-1 Dampens Inflammatory Cytokine Responses via Basophil Interleukin (IL)-4 and IL-13 (2018). Front. Immunol., 10 October 2018 | https://doi.org/10.3389/fimmu.2018.02293.

• Abla N, Keiser J, Vargas M, Reimers N, Haas H, Th. Spangenberg. Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model (2017). PLOS Neglected Tropical Diseases 11(9): e0005942. https://doi.org/10.1371/journal.pntd.0005942.

• Meyer NH, Mayerhofer H, Tripsianes K, Blindow S, Barths D, Mewes A, Weimar T, Köhli T, Bade S, Madl T, Frey A, Haas H, Mueller-Dieckmann J, Sattler M, Schramm G. A Crystallin Fold in the Interleukin-4-inducing Principle of Schistosoma mansoni Eggs (IPSE/alpha-1) mediates IgE Binding for Antigen-independent Basophil Activation (2015). J Biol Chem. 2015;290:22111-22126.

• Reimers N, Homann A, Höschler B, Langhans K, Wilson RA, Pierrot C, Khalife J, Grevelding CG, Chalmers IW, Yazdanbakhsh M, Hoffmann KR, Hokke CH, Haas H, Schramm G. Drug-induced Exposure of Schistosoma mansoni Antigens SmCD59a and SmKK7 (2015). PLoS Negl Trop Dis 9(3): e0003593. doi: 10.1371/journal.pntd.0003593

• Everts B, Hussaarts L, Driessen NN, Meevissen MHJ, Schramm G, Van der Ham AJ, Van der Hoeven B, Scholzen T, Burgdorf S, Mohrs M, Pearce EJ, Hokke CH, Haas H, Smits HH, Yazdanbakhsh M. Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor. J Exp Med 2012 Sep;209:1753–1767.

• Everts B, Perona-Wright G, Smits H, Hokke C, van der Ham A, Fitzsimmons C, Doenhoff M, van der Bosch J, Mohrs K, Haas H, Mohrs M, Yazdanbakhsh M, Schramm G. Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses. J Exp Med 2009 Aug;206:1673-1680.

• Schramm G, Mohrs K, Wodrich M, Doenhoff MJ, Pearce EJ, Haas H, Mohrs M. Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo. J Immunol. 2007;178:6023-6027.

• Schramm G, Gronow A, Knobloch J, Wippersteg V, Grevelding CG, Galle J, Fuller H, Stanley RG, Chiodini PL, Haas H, Doenhoff MJ. IPSE/alpha-1: A major immunogenic component secreted from Schistosoma mansoni eggs. Mol Biochem Parasitol. 2006;147:9-19.

• Schramm G, Falcone FH, Gronow A, Haisch K, Mamat U, Doenhoff MJ et al. Molecular characterization of an Interleukin-4-inducing factor from Schistosoma mansoni eggs. J Biol Chem 2003; 278:18384-18392.

• Falcone FH, Zahner H, Schlaak M, Haas H. Brugia malayi: In vitro cultivation of third-stage larvae to the young adult stage. Trop Med Parasitol. 1995;46:230-234.