Drug discovery on live worms*
helminGuard: Protection against / by parasitic worms (helminths)
helminGuard is specialized in the in vitro culture of schistosomes. Larvae from S. mansoni und S. haematobium mature under host-like conditions into adults including deposition of viable eggs and hatching of miracidia (more).
High throughput screening on live schistosomes
Employing in vitro-cultured schistosomes for screening compound libraries, the team of helminGuard identified several drug candidates with anthelminthic activity.
Advantages of helminGuard's in vitro approach
- Replacement of mammalian animal experiments according to the 3Rs concept.
- Relevant results, because compounds are tested on live worms in a host-like environment.
- Saving of time and costs for drug discovery (more).
*supported by the Federal Ministry for Education and Research Program “Alternative Methods to Animal Experiments”, BMBF/PTJ 0315277